Holiness in Scripture begins not with human effort but with divine declaration. God is holy β entirely other, set apart β and he calls his people to share in that character. The Hebrew word qadosh, translated "holy," means set apart, distinct, other than ordinary. When God commands "Be ye holy; for I am holy," he is calling his people to reflect what he already is.
In charismatic theology, sanctification is the ongoing work of the Holy Spirit in the believer's life. You are not left to manufacture holiness by moral exertion. The Spirit produces his fruit β love, joy, peace, patience β in a life surrendered to him. Holiness is less about what you stop doing and more about what fills the space when the Spirit takes over.
Hebrews 12:14 makes the stakes explicit: "without which no man shall see the Lord." This is not a peripheral pursuit. Holiness is the shape of the life that moves toward God. Not because it earns access β grace has already provided that β but because the holy life is the life that is increasingly aligned with what God is.
Commentary is from a charismatic Protestant perspective, drawing on KJV text and public-domain sources including Spurgeon, Andrew Murray, and Matthew Henry.