Romans 12:2 describes transformation that goes all the way down: "be ye transformed by the renewing of your mind." The Greek word metamorphoo — the same word used for the Transfiguration — describes a change not of surface but of form. The renewing of the mind is not behavior modification. It is a change in the underlying processing that generates behavior. This is the closest New Testament language to what modern psychology calls personality change — and Scripture locates the possibility in divine work, not human effort alone.
Lamentations 3:22–23 speaks into long, slow, difficult processes: "his compassions fail not. They are new every morning." For someone engaged in the long work of personality change through professional therapy — which often moves in small increments over years — the mercies being new every morning is not a platitude. It is the daily provision for a process that cannot be rushed. God is present in the slow work, not only the dramatic transformation.
Commentary is from a charismatic Protestant perspective, drawing on KJV text and public-domain sources including Spurgeon, Andrew Murray, and Matthew Henry.